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    To assess the effect of different doses of vitamin D supplementation on peripheral neuropathy in patients with type 2 diabetes mellitus T2DM. Sixteen subjects without diabetes will represent the control group. Részletes leírás It is well known that vitamin D deficiency along with type 2 diabetes mellitus T2DM is a modern pandemic. Development of microvascular complications in T2DM worsens both the prognosis and the patients' quality of life.

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    There is increasing evidence of a possible contribution of vitamin D deficiency to the pathogenesis of diabetes and its complications. A recent interventional prospective study demonstrated no decrease in the risk of T2DM development in patients with prediabetes after two-year treatment with 4, IU of vitamin D per day.

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    But, some experts suggested that 4, IU is not sufficient supplementation dose for patients with already existing impaired glucose metabolism and on the other hand most study participants had normal basal 25 OH D level. Along with immune-mediated mechanisms, microcirculation deterioration in patients with diabetes has been found to play an important role in the pathogenesis of microvascular complications including peripheral neuropathy DPN.

    It is believed that vitamin D deficiency diabetes disability group treatment plays a role in the progression of DPN. Thus, the correction of vitamin D deficiency in patients with T2DM is becoming increasingly attractive for the prevention and treatment of microvascular complications.

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    However, the question of the required vitamin D dose and the treatment duration remain highly debatable. The aim of this study was to assess the effect of therapy with different doses of cholecalciferol for 24 weeks on clinical manifestations of peripheral neuropathy, inflammatory markers, and parameters of microcirculation in patients with T2DM.

    Patients and Methods: Baseline characteristics will be recorded for all patients including Height, weight, BMI, diabetes status and biochemical parameters.

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    All will be repeated at 24 weeks. Blood will be collected after an overnight fast and stored at degrees until analysis.

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